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2036044-77-4

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2036044-77-4 Structure

2036044-77-4 Structure
IdentificationBack Directory
[Name]

Porcupine-IN-1
[CAS]

2036044-77-4
[Synonyms]

CS-2802
PORCN-IN-1
Porcupine-IN-1
Porcn inhibitor 1
9H-Carbazole-2-carboxamide, N-[(3-fluoro-2'-methyl[2,4'-bipyridin]-5-yl)methyl]-
[Molecular Formula]

C25H19FN4O
[MOL File]

2036044-77-4.mol
[Molecular Weight]

410.44
Chemical PropertiesBack Directory
[storage temp. ]

Store at -20°C
[solubility ]

DMF: 10 mg/ml; DMSO: 10 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml; Ethanol: slightly soluble
[form ]

A crystalline solid
[color ]

White to off-white
Safety DataBack Directory
[Symbol(GHS) ]


GHS07
[Signal word ]

Warning
[Hazard statements ]

H302-H315-H319-H335
[Precautionary statements ]

P261-P264-P270-P271-P280-P301+P312-P330-P302+P352-P321-P304+P340-P305+P351+P338-P332+P313-P362+P364-P337+P313-P403+P233-P405-P501
Hazard InformationBack Directory
[Description]

Porcupine-IN-1 is an inhibitor of the Wnt and hedgehog signaling pathways (IC50s = 0.5 and 71 nM, respectively, in cell-based reporter assays). It inhibits secretion of Wnt3A from Wnt3A-transfected HEK293T cells when used at a concentration of 0.1 μM, indicating inhibition of porcupine, an enzyme that catalyzes palmitoylation of Wnt proteins.
[Uses]

Porcupine-IN-1, is a potent porcupine inhibitor with an IC50 of 0.5±0.2 nM.
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