Identification | Back Directory | [Name]
3-Pyridinecarboxamide, 5-[2-[4-[2-(1H-indol-3-yl)ethyl]-1-piperazinyl]phenyl]-N-[3-(1-pyrrolidinyl)propyl]- | [CAS]
2043321-54-4 | [Synonyms]
AZ506 3-Pyridinecarboxamide, 5-[2-[4-[2-(1H-indol-3-yl)ethyl]-1-piperazinyl]phenyl]-N-[3-(1-pyrrolidinyl)propyl]- | [Molecular Formula]
C33H40N6O | [MOL File]
2043321-54-4.mol | [Molecular Weight]
536.71 |
Chemical Properties | Back Directory | [Boiling point ]
774.2±60.0 °C(Predicted) | [density ]
1.189±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 50 mg/mL (93.16 mM; Need ultrasonic) | [form ]
Solid | [pka]
13.22±0.46(Predicted) | [color ]
Light yellow to light brown |
Hazard Information | Back Directory | [Biological Activity]
AZ506 is a potent SMYD2 inhibitor with an IC50 of 17 nM. AZ506 inhibits SMYD2 methyltransferase activity in cells, leading to a decrease in the SMYD2-mediated methylation signal[1].
AZ506 inhibits SMYD2 mediated methylation of monomethyl p53 peptide in U2OS cells with an EC50 of 1.2 μM. AZ506 inhibits SMYD2-mediated methylation (p53-me in U2OS cells) with an IC50 of 2.43 μM[1]. | [storage]
Store at -20°C | [References]
[1]. Cowen SD, et al. Design, Synthesis, and Biological Activity of Substrate Competitive SMYD2 Inhibitors. J Med Chem. 2016;59(24):11079-11097. |
|
|