| Identification | Back Directory | [Name]
Tubulysin A,TubA | [CAS]
205304-86-5 | [Synonyms]
TubA
CS-1324
Tubulysin A
Tubulysins A
Tubulysin A,TubA
(2S,4R)-4-[[2-[(1R,3R)-1-acetyloxy-4-methyl-3-[3-methylbutanoyloxymethyl-[(2S,3S)-3-methyl-2-[[(2R)-1-methylpiperidine-2-carbonyl]amino]pentanoyl]amino]pentyl]-1,3-thiazole-4-carbonyl]amino]-5-(4-hydroxyphenyl)-2-methylpentanoicaci
Benzenepentanoic acid, γ-[[[2-[(1R,3R)-1-(acetyloxy)-4-methyl-3-[[(2S,3S)-3-methyl-2-[[[(2R)-1-methyl-2-piperidinyl]carbonyl]amino]-1-oxopentyl][(3-methyl-1-oxobutoxy)methyl]amino]pentyl]-4-thiazolyl]carbonyl]amino]-4-hydroxy-α-methyl-, (αS,γR)- | [Molecular Formula]
C43H65N5O10S | [MDL Number]
MFCD12912448 | [MOL File]
205304-86-5.mol | [Molecular Weight]
844.07 |
| Chemical Properties | Back Directory | [Melting point ]
106-108 °C(Solv: methanol (67-56-1); water (7732-18-5)) | [Boiling point ]
979.9±65.0 °C(Predicted) | [density ]
1.195±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
organic solvents: soluble | [form ]
film | [pka]
4.52±0.23(Predicted) | [color ]
colorless or white |
| Hazard Information | Back Directory | [Uses]
Tubulysin A is a novel antibiotic, which is anti-microtubule, anti-mitotic, an apoptosis inducer, anticancer, anti-angiogenic, and antiproliferative. | [Definition]
ChEBI: Tubulysin A is a diester and a carboxylic acid. | [Biochem/physiol Actions]
Tubulysin A is a novel antibiotic, which is anti-microtubule, anti-mitotic, apoptosis inducer, anticancer, anti-angiogenic, and antiproliferative. Tubulysins are cytotoxic peptides, which include 9 members (A-I). Tubulysin A has potential application as an anticancer agent. It arrests cells in the G2/M phase. Tubulysin A inhibits polymerization more efficiently than vinblastine and induces depolymerization of isolated microtubules. Tubulysin A has potent cytostatic effects on various tumor cell lines with IC50 in the picomolar range. |
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