| Identification | Back Directory | [Name]
2,5-Piperazinedione, 3-[[5-(1,1-dimethylethyl)-1H-imidazol-4-yl]methylene-d]-6-(phenylmethylene)-, (3Z,6Z)- | [CAS]
2054938-28-0 | [Synonyms]
MBRI 001
MBRI-001
NPI-2358-d
plinabulin-d
MBRI001. BPI-2358-d
2,5-Piperazinedione, 3-[[5-(1,1-dimethylethyl)-1H-imidazol-4-yl]methylene-d]-6-(phenylmethylene)-, (3Z,6Z)- | [Molecular Formula]
C19H20N4O2 | [MOL File]
2054938-28-0.mol | [Molecular Weight]
336.4 |
| Hazard Information | Back Directory | [Description]
MBRI-001 is a deuterium-substituted plinabulin derivative as a potent anti-cancer agent. MBRI-001 exhibited better pharmacokinetic characteristics than that of plinabulin. Additionally, its antitumor activity is in a low nanomolar level for a variety of cancer cell lines and high activity against human NCI-H460 xenograted in mice intravenous administration. Importantly, continuous administration of MBRI-001 exhibited lower toxicity compared to docetaxel. |
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