| Identification | Back Directory | [Name]
Bis-sulfone-peg12-nhs ester | [CAS]
2055105-51-4 | [Synonyms]
Bis-sulfone-peg12-nhs ester | [Molecular Formula]
C56H80N2O22S2 | [MDL Number]
MFCD30458026 |
| Hazard Information | Back Directory | [Description]
Bis-sulfone-PEG12-NHS Ester is a bis-alkylating labeling reagent that is selective for the cysteine sulfur atoms from a native disulfide. These reagents undergo bis-alkylation to conjugate both thiols derived from the two cysteine residues of a reduced native disulfide bond such as the interchain disulfide bonds of an antibody. The reaction results in covalent rebridging of the disulfide bond via a three carbon bridge leaving the protein structurally intact. The hydrophilic PEG spacer increases solubility in aqueous media. |
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