| Identification | Back Directory | [Name]
Rutaecarpine | [CAS]
20575-76-2 | [Synonyms]
Ai3-51108
Nsc 255317
Brn 2116874
Rutaecarpine
1,1'-Hexamethylenebis[3,3-dimethylurea]
3,3'-HEXAMETHYLENEBIS(1,1-DIMETHYLUREA)
Urea, 1,1'-hexamethylenebis(3,3-dimethyl-
N,N''-1,6-Hexanediylbis[N',N'-dimethylurea]
Urea, N,N''-1,6-hexanediylbis(N',N'-dimethyl-(9ci)
3-[6-(dimethylcarbamoylamino)hexyl]-1,1-dimethyl-urea | [Molecular Formula]
C12H26N4O2 | [MDL Number]
MFCD00025668 | [MOL File]
20575-76-2.mol | [Molecular Weight]
258.36 |
| Hazard Information | Back Directory | [Biological Functions]
Rutaecarpine also inhibits accumulation of macrophages and cholesterol in atherosclerotic lesions and increases cholesterol excretion in other animal models. Additionally, rutaecarpine inhibits hypoxia-induced production of ROS and lactate dehydrogenase and suppresses apoptosis in myocardiocytes. In other cellular models, rutaecarpine decreases corticosterone production, potentially through inhibition of cAMP, 3β-hydroxysteroid dehydrogenase, and 11β-hydroxylase activity. | [Biological Activity]
Rutaecarpine is an indoloquinazoline alkaloid originally found in Evodia; it exhibits anti-inflammatory, anti-atherosclerotic, cardioprotective, anorexigenic, and anti-obesity activities. Rutaecarpine inhibits COX-2 and also decreases food intake, weight gain, and serum glucose, leptin, and insulin levels in vivo by inhibiting expression of neuropeptide Y and AgRP. | [Mechanism of action]
Rutaecarpine also inhibits production of ROS, NO, and iNOS, potentially through inhibition of NADPH oxidase. In macrophages, rutaecarpine inhibits arachidonic acid release and decreases production of prostaglandin E2 (PGE2); in other in vitro models, it inhibits collagen-stimulated formation of thromboxane B2 and inosine monophosphate. |
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www.cuichengbio.com/ |
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CHEMSWORTH
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www.chemsworth.com |
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