ChemicalBook--->CAS DataBase List--->2062200-97-7

2062200-97-7

2062200-97-7 Structure

2062200-97-7 Structure
IdentificationBack Directory
[Name]

XL413 (hydrochloride)
[CAS]

2062200-97-7
[Synonyms]

XL-413 hydrochloride,XL413 hydrochloride
[Molecular Formula]

C14H13Cl2N3O2
[MOL File]

2062200-97-7.mol
[Molecular Weight]

326.18
Chemical PropertiesBack Directory
[storage temp. ]

Store at -20°C
[solubility ]

DMSO:0.2(Max Conc. mg/mL);0.613(Max Conc. mM)
PBS (pH:7.2):10.0(Max Conc. mg/mL);30.66(Max Conc. mM)
[form ]

A crystalline solid
[color ]

White to off-white
Hazard InformationBack Directory
[Description]

XL413 is a potent inhibitor of Cdc7 (IC50 = 3.4 nM). It is >60, >10, and >300-fold selective for Cdc7 over CK2, PIM1, and a panel of over 100 protein kinases, respectively. XL413 inhibits the growth of MDA-MB-231T and COLO 205 cells (IC50s = 118 and 140 nM, respectively). It inhibits Cdc7-specific phosphorylation of mini-chromosome maintenance protein (MCM2) and induces cell cycle accumulation in the S and G2 phases in MDA-MB-231T and COLO 205 cells that overexpress Cdc7. In vivo, XL413 inhibits MCM2 phosphorylation (ED50 = <3 mg/kg) and reduces tumor growth in a COLO 205 mouse xenograft model when administered orally at doses of 10, 30, and 100 mg/kg.
[storage]

Store at -20°C
2062200-97-7 suppliers list
Company Name: BOC Sciences  
Tel: 16314854226
Website: www.bocsci.com
Company Name: Shanghai EFE Biological Technology Co., Ltd.  
Tel: 021-65675885 18964387627
Website: http://www.efebio.com
Company Name: Shanghai Rechem science Co., Ltd.  
Tel: 21-31433387 15618786686
Website: cn.rechemscience.com
Company Name: Beijing Jin Ming Biotechnology Co., Ltd.  
Tel: 010-60605840 18892239720
Website: www.jm-bio.com/
Company Name: Chengdu Saint - Kay Biotechnology Co., Ltd.  
Tel: 028-85157043 15882256948
Website: https://www.chemicalbook.com/ShowSupplierProductsList30701/0.htm
Company Name: Fan De(Beijing) Biotechnology Co., Ltd.  
Tel: 15911056312
Website: www.bio-fount.com
Company Name: ChemeGen(Shanghai) Biotechnology Co.,Ltd.  
Tel: 18818260767
Website: www.chemegen.com
Company Name: Shanghai hongqu biomedical technology co. LTD  
Tel: 88888888888
Website: www.chemicalbook.com/ShowSupplierProductsList873228/0.htm
Company Name: Beijing Jin Ming Biotechnology Co., Ltd.  
Tel: 010-60605840
Website: www.jm-bio.com/
Company Name: TargetMol Chemicals Inc.  
Tel: 4008200310
Website: https://www.targetmol.cn/
Company Name: Shanghai?Medlife?Pharm-Tech?Co.,?Ltd  
Tel: 021-59167510 18117107507
Website: www.med-life.cn/
Company Name: RD International Technology Co., Limited  
Tel: 18024082417
Website: www.ruidiresearch.com
Company Name: Cayman Chemical Company  
Tel: (800) 364-9897
Website: www.caymanchem.com
Company Name: MedChemExpress  
Tel: 021-58955995
Website: www.medchemexpress.com
Company Name: Shanghai Hao Zhun Biological Technology Co., Ltd.  
Tel: 15800340161
Website: www.zzsrm.com
Tags:2062200-97-7 Related Product Information