| Identification | Back Directory | [Name]
4-METHOXYPYRIDAZINE | [CAS]
20733-11-3 | [Synonyms]
4-METHOXYPYRIDAZINE
4-Methoxy-pyridazin
Pyridazine, 4-methoxy-
4-methoxypyridazine hydrochloride
4-METHOXYPYRIDAZINE ISO 9001：2015 REACH | [Molecular Formula]
C5H6N2O | [MDL Number]
MFCD08236840 | [MOL File]
20733-11-3.mol | [Molecular Weight]
110.11 |
| Chemical Properties | Back Directory | [Melting point ]
43-44℃ | [Boiling point ]
244℃ | [density ]
1.102 | [Fp ]
89℃ | [storage temp. ]
Sealed in dry,Room Temperature | [pka]
4.28±0.10(Predicted) |
| Hazard Information | Back Directory | [Uses]
To a solution of 3 ,6-dichloro-4- methoxypyridazine (30 g, 167.59 mmol, 1.00 equiv) and ammonium formate (3 1 g, 491.63 mmol, 2.93 equiv) in MeOH (500 mL) was added 10% palladium on carbon (3 g) catalyst. The mixture was stirred under 1 atmosphere of at rt overnight. The catalyst was removed by filtration and the filtrate was concentrated under vacuum. The residue was triturated in 500 mL of DCM MeOH ( 10: 1 ) and the solid material was filtered out. The filtrate was concentrated under vacuum and the residue was purified on a silica gel column eluted with ethyl acetate/petroleum ether (2:1 to 1: 1) to give 1 5 g (81%) of 4-methoxypyridazine as a brown oil. TLC: petroleum ether: ethyl acetate=2: 1 , Rf=0.1 . | [Uses]
4-methoxypyridazine can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process. |
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