[Description]
c-met-IN-1 (compound 16) is a potent and selective c-Met inhibitor, with IC50 of 1.1 nM, with antitumor activity.[1].
IC50: 1.1 nM (c-Met)[1] c-met-IN-1 (compound 16) exhibits high selectivity and remarkable cytotoxicity against HT-29, MKN-45 and A549 cells with IC50 values of 0.08 μM, 0.22 μM and 0.07 μM, respectively[1]. |