| Identification | Back Directory | [Name]
Rpaf-ah | [CAS]
208576-22-1 | [Synonyms]
Pafase
Rpaf-ah
Epafipase
PAF-AH human
PAF 2-acylhydrolase
Paf acetylhydrolase
Epafipase [usan:inn]
LDL-associated phospholipase A2
Deacetylase, 1-alkyl-2-acetyllecithin (human)
2-acetyl-1-alkylglycerophosphocholine esterase
2-Acetyl-1-alkyl-sn-glycero-3-phosphocholine deacetylase-(6-400)-peptide (human) |
| Hazard Information | Back Directory | [Uses]
Antiallergenic;
antiasthmatic (PAF antagonist [PAF acetylhydrolasemphor.]. | [General Description]
Recombinant PAF-AH is a 420 amino acid glycoprotein which migrates with an apparent molecular mass of 47-55kDa by SDS-PAGE analysis. | [Biochem/physiol Actions]
Platelet Activating Factor (PAF) is a biologically active phospholipid, which exerts primarily proinflammatory activities by specifically signaling through G-protein-coupled receptors on platelets, neutrophils, and monocytes. Platelet activating factor acetylhydrolase (PAF-AH) is a secreted protein that mediates PAF activity by specifically catalyzing hydrolysis of the "sn2" ester bond, resulting in the conversion of PAF to the biologically inactive lyso-PAF. PAF-AH can also interact with LDL (low density lipoprotein) particles to induce the hydrolysis of LDL associated, oxidized phospholipids, generating lysophosphatidylcholine (lyso-PC) and other lysophospholipids. High levels of PAF-AH in plasma can be an indication of resistant hypertension. Polymorphism in PAF-AH gene at A379V might be linked with ischemic stroke susceptibility. |
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