| Identification | Back Directory | [Name]
1-((1-(tert-Butoxycarbonyl)azetidin-3-yl)methyl)-1H-pyrazole-4-carboxylic acid | [CAS]
2095672-42-5 | [Synonyms]
Rigid linker for PROTAC? development
1-((1-(tert-Butoxycarbonyl)azetidin-3-yl)methyl)-1H-pyrazole-4-carboxylic acid
1H-Pyrazole-4-carboxylic acid, 1-[[1-[(1,1-dimethylethoxy)carbonyl]-3-azetidinyl]methyl]- | [Molecular Formula]
C13H19N3O4 | [MOL File]
2095672-42-5.mol | [Molecular Weight]
281.31 |
| Chemical Properties | Back Directory | [Boiling point ]
450.7±15.0 °C(Predicted) | [density ]
1.32±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [form ]
powder | [pka]
3.87±0.10(Predicted) |
| Hazard Information | Back Directory | [Uses]
1-((1-(tert-Butoxycarbonyl)azetidin-3-yl)methyl)-1H-pyrazole-4-carboxylic acid is useful as a rigid linker in PROTAC development for targeted protein degradation as well as chemical conjugates. Incorporation of rigidity into the linker region of bifunctional protein degraders may impact the 3D orientation of the degrader and thus ternary complex formation as well as optimization of drug-like properties. Developed in partnership with ComInnex.
Similar linkers in this series:
920487
920495
920584
ADV638390284 | [reaction suitability]
reagent type: linker |
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