| Identification | Back Directory | [Name]
ERK1/2 inhibitor 1 | [CAS]
2095719-90-5 | [Synonyms]
ERK1/2 INHIBITOR 1
2H-Isoindole-2-acetamide, 6-[5-chloro-2-[(tetrahydro-2H-pyran-4-yl)amino]-4-pyrimidinyl]-1,3-dihydro-N-[(1S)-2-hydroxy-1-(3-methylphenyl)ethyl]-α-methyl-1-oxo-, (αR)- | [Molecular Formula]
C29H32ClN5O4 | [MDL Number]
MFCD31813665 | [MOL File]
2095719-90-5.mol | [Molecular Weight]
550.06 |
| Chemical Properties | Back Directory | [density ]
1.344±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 250 mg/mL (454.50 mM; Need ultrasonic) | [form ]
Solid | [pka]
13.73±0.46(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Biological Activity]
ERK1/2 inhibitor 1 is a potent, orally bioavailable ERK1/2 inhibitor, showing 60% inhibition at 1 nM and an IC50 of 3.0 nM against ERK1 and ERK2, respectively[1].
ERK1/2 inhibitor 1 (Compound 27) shows excellent antiproliferative potency with IC50s of 4.9 and 7.5 nM in A375 and Colo205 cells, respectively[1]. | [References]
[1]. Heightman TD, et al. Fragment-Based Discovery of a Potent, Orally Bioavailable Inhibitor That Modulates the Phosphorylation and Catalytic Activity of ERK1/2. J Med Chem. 2018 Jun 14;61(11):4978-4992. |
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| Company Name: |
cjbscvictory
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| Tel: |
13348960310 13348960310 |
| Website: |
http://www.weikeqi-biotech.com/ |
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