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2096455-90-0

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2096455-90-0 Structure

2096455-90-0 Structure
IdentificationBack Directory
[Name]

PF-3893787 hydrochloride
[CAS]

2096455-90-0
[Synonyms]

PF-3893787 hydrochloride
Adriforant hydrochloride
[Molecular Formula]

C13H25ClN6O
[MDL Number]

MFCD31630832
[MOL File]

2096455-90-0.mol
[Molecular Weight]

316.83
Chemical PropertiesBack Directory
[storage temp. ]

Store at -20°C
[solubility ]

DMSO : ≥ 83.33 mg/mL (224.16 mM)
[form ]

Solid
[color ]

White to off-white
Hazard InformationBack Directory
[Biological Activity]

Adriforant hydrochloride (PF-3893787 hydrochloride) is a novel histamine H4 receptor affinity antagonist (Ki=2.4 nM) and a functional H4 receptor antagonist (Ki=1.56 nM).
[in vitro]

Adriforant is tested and observed binding K i =2.4 nM and functional K i =1.56 nM for H4R. Data from functional assays produce convergent projections of the free plasma efficacious concentration and Adriforant (Compound 13) is fast on/fast off on rhH4R.
[target]

Ki: 2.4 nM (H4R bind), 1.56 nM (H4R func)

[storage]

Store at -20°C
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