| Identification | Back Directory | [Name]
1H-Pyrazole-4-carboxamide, 5-amino-3-[4-[[(5-fluoro-2-methoxybenzoyl)amino]methyl]phenyl]-1-[(1R)-2,2,2-trifluoro-1-methylethyl]- | [CAS]
2101700-14-3 | [Synonyms]
(R)-Pirtobrutinib
1H-Pyrazole-4-carboxamide, 5-amino-3-[4-[[(5-fluoro-2-methoxybenzoyl)amino]methyl]phenyl]-1-[(1R)-2,2,2-trifluoro-1-methylethyl]- | [Molecular Formula]
C22H21F4N5O3 | [MDL Number]
MFCD34567317 | [MOL File]
2101700-14-3.mol | [Molecular Weight]
479.43 |
| Chemical Properties | Back Directory | [Boiling point ]
619.2±55.0 °C(Predicted) | [density ]
1.44±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 200 mg/mL (417.16 mM; Need ultrasonic) | [form ]
Solid | [pka]
13.32±0.46(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Biological Activity]
(R)-Pirtobrutinib ((R)-LOXO-305) is a less active enantiomer of Pirtobrutinib. Pirtobrutinib (LOXO-305), a highly selective and non-covalent next generation BTK inhibitor, inhibits diverse BTK C481 substitution mutations[1]. | [References]
[1]. Gomez E B , et al. Loxo-305, a Highly Selective and Non-Covalent Next Generation BTK Inhibitor, Inhibits Diverse BTK C481 Substitution Mutations[J]. Blood, 2019, 134(Supplement_1):4644-4644. |
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