| Identification | Back Directory | [Name]
HA-100 (hydrochloride) | [CAS]
210297-47-5 | [Synonyms]
HA-100 dihydrochloride
DISCONTINUED, Offer I891000
5-piperazin-1-ylsulfonylisoquinoline:dihydrochloride | [Molecular Formula]
C13H15N3O2S?2HCl | [MDL Number]
MFCD01310980 | [MOL File]
210297-47-5.mol | [Molecular Weight]
313.8 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
insoluble in EtOH; ≥131.8 mg/mL in H2O; ≥19.17 mg/mL in DMSO with ultrasonic | [form ]
A crystalline solid |
| Hazard Information | Back Directory | [Description]
HA-100 is an isoquinoline compound with an added piperazinylsulfonyl group that acts as an inhibitor of protein kinases (PKs), including PKA, PKC, and PKG (IC50s = 8, 12, and 4 μM, respectively). It less effectively blocks the activity of myosin light chain kinase (IC50 = 240 μM). | [Uses]
HA-100 dihydrochloride is an inhibitor of MYLK, PKA, and PKC. | [References]
[1] hagiwara m, inagaki m, watanabe m, et al. selective modulation of calcium-dependent myosin phosphorylation by novel protein kinase inhibitors, isoquinolinesulfonamide derivatives[j]. molecular pharmacology, 1987, 32(1): 7-12.
[2] krebs e g. protein kinases[j]. current topics in cellular regulation, 1972, 5: 99-133. |
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