| Identification | Back Directory | [Name]
4,6-Pyrimidinediamine, 2-[[(1R)-1-[2-[4-methoxy-3-[2-(4-morpholinyl)ethoxy]phenyl]-5-methyl-4-thiazolyl]ethyl]thio]- | [CAS]
2107280-55-5 | [Synonyms]
DI-87
4,6-Pyrimidinediamine, 2-[[(1R)-1-[2-[4-methoxy-3-[2-(4-morpholinyl)ethoxy]phenyl]-5-methyl-4-thiazolyl]ethyl]thio]- | [Molecular Formula]
C23H30N6O3S2 | [MOL File]
2107280-55-5.mol | [Molecular Weight]
502.65 |
| Chemical Properties | Back Directory | [Boiling point ]
748.9±70.0 °C(Predicted) | [density ]
1.37±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [form ]
Solid | [pka]
6.39±0.10(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Biological Activity]
DI-87 is an orally active and selective deoxycytidine kinase (dCK) inhibitor with an EC50 of 10.2 nM. DI-87 has antitumor activity and is used in combination therapy against tumors expressing dCK[1].
(S)-DI-87 exhibits a much higher IC50 value (IC50=468 nM) relative to DI-87 ((R)-DI-8) (IC50=3.15 nM) in CEM T-ALL cells for inhibition of dCK activity[1]. DI-87 (1 μM; for 72 hours) rescues human cell line CCRF-CEM (CEM) cells from the anti-proliferative effects of gemcitabine, a dCK-dependent nucleoside analog prodrug, with an EC50 of 10.2 nM[1].
DI-87 (5-25 mg/kg; oral gavage) exhibits full dCK inhibition for 27 hours, and enzyme activity fully recovered by 36 hours with 25 mg/kg dose[1]. DI-87 (10-50 mg/kg; oral) has plasma concentrations of between 1 and 3 hours and plasma half-life of 4 hours[1]. DI-87 (10 mg/kg/day or 25 mg/kg/twice a day; oral; for 16-18 days) with thymidine (2 g/kg; ip; twice a day) results in reduced tumor growth in male NSG mice implanted with CEM tumors[1]. | [References]
[1]. Soumya Poddar, et al. Development and Preclinical Pharmacology of a Novel dCK Inhibitor, DI-87. Biochem Pharmacol. 2020 Feb;172:113742. |
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