| Identification | Back Directory | [Name]
QRX 431 | [CAS]
211110-63-3 | [Synonyms]
GC-1
EIEE3
NET44
QRX 431
Anti-GC1
Anti-OlfD
Anti-NET44
SobetiroMe
Anti-GW112
Anti-KIAA4294
GC-1; QRX-431
Anti-FLJ13044
Anti-bA209J19.1
GC-1 (Sobetirome)
Anti-Olfactomedin 4
GC 1 (pharmaceutical)
Sobetirome >=98% (HPLC)
Anti-SLC25A22 antibody produced in rabbit
Anti-SLC25A22, (N-terminal) antibody produced in rabbit
[3,5-Dimethyl-4-(4-hydroxy-3-isopropylbenzyl)phenoxy]acetic acid
2-(4-(4-Hydroxy-3-isopropylbenzyl)-3,5-dimethylphenoxy)acetic acid
[4-(4-Hydroxy-3-isopropyl-benzyl)-3,5-dimethyl-phenoxy]-acetic acid
Anti-solute carrier family 25 (mitochondrial carrier: glutamate), member 22
2-[4-[[4-Hydroxy-3-(1-methylethyl)phenyl]methyl]-3,5-dimethylphenoxy]acetic acid
Acetic acid, 2-[4-[[4-hydroxy-3-(1-methylethyl)phenyl]methyl]-3,5-dimethylphenoxy]- | [Molecular Formula]
C20H24O4 | [MDL Number]
MFCD19443713 | [MOL File]
211110-63-3.mol | [Molecular Weight]
328.4 |
| Chemical Properties | Back Directory | [Melting point ]
122 - 124°C | [Boiling point ]
510.2±45.0 °C(Predicted) | [density ]
1.152±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
DMSO: soluble10mg/mL, clear | [form ]
powder | [pka]
3.22±0.10(Predicted) | [color ]
white to beige | [InChIKey]
QNAZTOHXCZPOSA-UHFFFAOYSA-N |
| Hazard Information | Back Directory | [Uses]
GC 1 is a high affinity thyroid receptor α (TRα) and TRβ agonist. | [Definition]
ChEBI: Sobetirome is a diarylmethane. | [Biological Activity]
sobetirome (3,5-dimethyl-4[(4'-hydroxy-3'-isopropylbenzyl)-phenoxy] acetic acid, also known as gc-1 and qrx-431, is a member of a class of compounds known as selective thyromimetics.it was firstly developed by thomas scanlan’s group at the university of california-san francisco (ucsf) in 1995 1.in cholesterol-fed rats, sobetirome was shown to lower plasma cholesterol in a dose-dependent manner by up to 75% of untreated controls. in hypercholesterolemic mice, sobetirome was failed to induce ldl receptor mrna expression. in different mouse models, sobetirome and t-0681 were shown to promote bile acid production and biliary sterol secretion. in cynomolgus monkeys, sobetirome was shown to reduce plasma cholesterol in a dose-dependent manner by up to 30%. both sobetirome and t-0681 were shown to increase hepatic expression of the hdl receptor (scavenger receptor-bi, sr-bi) in animals.in phase i | [Biochem/physiol Actions]
Sobetirome is also termed as 2-(4-(4-(benzyloxy)-3-isopropylbenzyl)-3,5-dimethylphenoxy)acetic acid/ GC-1. It has an inner-ring and negatively charged carboxylate groups at physiological pH. Sobetirome is considered as a cholesterol lowering agent in humans. | [storage]
Store at -20°C | [References]
1. tancevski i, demetz e, eller p. sobetirome: a selective thyromimetic for the treatment of dyslipidemia. recent pat cardiovasc drug discov. 2011 jan;6(1):16-9. |
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Cochemical Ltd. Gold
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029-86115547 17791676824 |
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www.cochemical.com |
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Sigma-Aldrich
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021-61415566 800-8193336 |
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https://www.sigmaaldrich.cn |
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SPIRO PHARMA
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www.spiropharma.com.cn |
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