| Identification | Back Directory | [Name]
Vitamin K2(35) | [CAS]
2124-57-4 | [Synonyms]
MK-7
Vitamin MK 7
MENAQUINONE-7
Menaquinone K7
Vitamin K2(35)
Menlaquinone 7
Menaquinone-7 Standard
Menaquinone 7, Synthetic
Menaquinone 7, Synthetic (90%)
(all-E)-2-(3,7,11,15,19,23,27-Heptamethyl-2,6,10,14,18,22,26-octacosaheptaenyl)-3-methyl-1,4-naphthalenedione
2-[(2E,6E,10E,14E,18E,22E)-3,7,11,15,19,23,27-Heptamethyl-2,6,10,14,18,22,26-octacosaheptenyl]-3-methyl-1,4-naphthalenedione | [Molecular Formula]
C46H64O2 | [MDL Number]
MFCD06200757 | [MOL File]
2124-57-4.mol | [Molecular Weight]
649 |
| Chemical Properties | Back Directory | [Appearance]
Light Yellow Crystalline Solid | [Melting point ]
54 °C | [Boiling point ]
bp0.0002 200° (some dec) | [density ]
0.961 | [storage temp. ]
-20°C | [solubility ]
Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly) | [form ]
Solid | [color ]
Pale Yellow to Yellow Gel to | [Stability:]
Light and Temperature Sensitive | [InChIKey]
RAKQPZMEYJZGPI-LJWNYQGCSA-N | [SMILES]
C1(=O)C2=C(C=CC=C2)C(=O)C(C)=C1C/C=C(\C)/CC/C=C(\C)/CC/C=C(\C)/CC/C=C(\C)/CC/C=C(\C)/CC/C=C(\C)/CC/C=C(/C)\C | [LogP]
14.451 (est) |
| Hazard Information | Back Directory | [Chemical Properties]
Light Yellow Crystalline Solid | [Uses]
Menaquinones are isoprenoid quinones of the naphthalene series and belongs to the K2 Vitamin homologs. Menaquinones were originally discovered as the anti-hemorrhagic factor and now encompasses a vari
ety of physiological processes. Menaquinone 7 belongs to the class of K2-Vitamins homologs. Menaquinone 7 has been identified as the most bioactive cofactor for the carboxylation reaction of Gla-prote
ins such as osteocalcin and matrix-Gla protein, which plays a crucial role in building and maintaining overall bone health. | [Uses]
Vitamin (prothrombogenic) | [Definition]
ChEBI: A menaquinone whose side-chain contains seven isoprene units in an all-trans-configutation. | [Description]
Menaquinone 7 (MK-7) is a vitamin K2 analog that has been found in a variety of fermented foods.1 It increases osteocalcin, osteoprotegerin, and RANKL mRNA expression in osteoblastic MC3T3E cells. MK-7 (1 μM) increases alkaline phosphatase activity and calcium content in femoral-metaphyseal tissues isolated from normal and skeletal-unloaded rats.2 In vivo, MK-7 (100 μg/g diet) inhibits aortic and myocardial calcification and decreases aortic alkaline phosphatase tissue concentrations in a rat model of extraosseous calcification.3 It also increases trabecular number, bone mineral density, and bone mineral content in a rat model of ovariectomy-induced bone loss.4 | [General Description]
Vitamin K2, also known as menaquinone, is a polyisoprenoid-substituted?napthoquinone. Menaquinone-7 (MK-7) is a subtype of vitamin K2. It is found in animals, soy protein, fermented products and is primarily produced by bacteria.
Vitamin K2 (MK-7)-(5,6,7,8-d4,2-methyl-d3) is a deuterated vitamin K2 wherein C-5, C-6, C-7, C-8, and 2-methyl protons are replaced by deuterium. |
| Questions And Answer | Back Directory | [Structure]
Vitamin K2 is a fat-soluble vitamin that has the ability to cross the blood-brain barrier (BBB) due to its lipophilic nature. All the existing forms of vitamin K2 consist of a common moiety in their chemical structure, which is a 2-methyl-1,4-naphthoquinone ring. This core chemical structure of vitamin K2 is called menadione. Each form differs from the others with respect to the degree of saturation and length of side chains. Menaquinone (also called MK-n) differs in the length of its side chain, varying from 4 to 15 isoprene units; n denotes the number of isoprene units present in the structure. The figure depicts the chemical structures of members of the vitamin K2 family. The differences in side chains of different forms give each of them a unique potency and absorption efficiency. Menaquinones with the absence of methyl group on naphthoquinone moiety at position 3 are called dimethyl-menaquinones and serve as precursors to menaquinone.
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