| Identification | Back Directory | [Name]
PD184352 | [CAS]
212631-79-3 | [Synonyms]
CS-333
Ci-1040
PD184352
PD 184352, >=98%
PD184352 USP/EP/BP
CI-1040, PD-184352
PD 184352;CI-1040;PD-184352
CI1040;PD-184352; CI 1040 (PD184352)
2-[(2-CHLORO-4-IODOPHENYL) AMINO]-N-(CYCLOPROPYLME
2-(2-CHLORO-4-IODOANILINO)-N-(CYCLOPROPYLMETHOXY)-3,4-DIFLUOROBENZAMIDE
3,4-Difluoro-2-(2-chloro-4-iodophenylaMino)-N-cyclopropylMethoxybenzaMide
2-[(2-Chloro-4-iodophenyl)amino]-N-(cyclopropylmethoxy)-3,4-difluorobenzamide
Benzamide, 2-[(2-chloro-4-iodophenyl)amino]-N-(cyclopropylmethoxy)-3,4-difluoro-
CI-10402-(2-chloro-4-iodophenylamino)-N-(cyclopropylmethoxy)-3,4-difluorobenzamide
2-(2-Chloro-4-iodophenylamino)-N-(cyclopropylmethoxy)-3,4-difluorobenzamide PD184352 | [Molecular Formula]
C17H14ClF2IN2O2 | [MDL Number]
MFCD02683961 | [MOL File]
212631-79-3.mol | [Molecular Weight]
478.66 |
| Chemical Properties | Back Directory | [Melting point ]
166-169°C | [density ]
1.747±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C Freezer | [solubility ]
DMSO: ≥30mg/mL | [form ]
powder | [pka]
-5.58±0.50(Predicted) | [color ]
white to tan |
| Hazard Information | Back Directory | [Chemical Properties]
Off-White to Pale Beige Solid | [Uses]
An inhibitor of ERK signaling pathway. A MAP kinase inhibitor | [Definition]
ChEBI: 2-(2-chloro-4-iodoanilino)-N-(cyclopropylmethoxy)-3,4-difluorobenzamide is an aminobenzoic acid. | [Biological Activity]
Potent and selective inhibitor of MAPK (ERK kinase 1; MEK1) activation (IC50=300nM in vitro, IC50=2nM in vivo). Suppresses activation of MAPK but does not block its activity. Strongly suppresses growth of human implanted colon tumors in mice. | [Biochem/physiol Actions]
PD184352 (CI-1040) is a highly selective non-competitive inhibitor of MEK (MKK1; MAPK kinase) and the closely related MKK2. It has anti-cancer activity, suppresses the ERK pathway, and has been used along with other classes of inhibitors to establish embryonic stem cell lines. | [Enzyme inhibitor]
This substituted benzamide (FW = 478.66 g/mol), also known as 2- (chloro-
4-iodophenylamino) -N-cyclopropylmethoxy-3,4-difluorobenzamide and CI-
1040, inhibits ERK activation, IC50 = 16 nM. | [storage]
Store at -20°C | [References]
[1] frémin c, meloche s. from basic research to clinical development of mek1/2 inhibitors for cancer therapy. j hematol oncol. 2010 feb 11;3:8. doi: 10.1186/1756-8722-3-8. |
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