| Identification | Back Directory | [Name]
COMPOUND 52 | [CAS]
212779-48-1 | [Synonyms]
NG-52
COMPOUND 52
NG-52, >98%
NG 52 (Compound 52 )
NG52; COMPOUND52;NG-52;COMPOUND-52
2-(2-HYDROXYETHYLAMINO)-6-(3-CHLORANILINO)-9-ISOPROPYLPURINE
2-(2-HYDROXYETHYLAMINO)-6-(3-CHLOROANILINO)-9-ISOPROPYLPURINE
2-[[6-(3-chloroanilino)-9-propan-2-ylpurin-2-yl]amino]ethanol
2-(2-Hydroxyethylamino)-6-(3-chloroanilino)-9-isopropylpurine, NG-52
2-((6-((3-chlorophenyl)aMino)-9-isopropyl-9H-purin-2-yl)aMino)ethanol
2-[[6-[(3-Chlorophenyl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino]ethanol
Ethanol, 2-[[6-[(3-chlorophenyl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino]- | [Molecular Formula]
C16H19ClN6O | [MDL Number]
MFCD02179196 | [MOL File]
212779-48-1.mol | [Molecular Weight]
346.81 |
| Chemical Properties | Back Directory | [Boiling point ]
587.7±60.0 °C(Predicted) | [density ]
1.42±0.1 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Sealed in dry,2-8°C | [solubility ]
methylene chloride: 50 mg/mL, clear, colorless
| [form ]
powder
| [pka]
14.54±0.10(Predicted) | [color ]
white to off-white
|
| Hazard Information | Back Directory | [Description]
NG 52 is a tri-substituted purine that binds to the ATP-binding site of yeast cyclin-dependent kinases, inhibiting Cdc28p and Pho85p (IC50s = 7 and 2 μM, respectively). It is ineffective against the yeast kinases Kin28p, Srb10, and Cak1p. NG 52 is cell permeable and inhibits the growth of S. cerevisiae (GI50 = 30 μM). It is an analog of purvalanol A , a potent inhibitor of mammalian cyclin-dependent kinases. |
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