| Identification | Back Directory | [Name]
Fenebrutinib (GDC-0853) HCl | [CAS]
2128304-54-9 | [Synonyms]
RG7845
RG-7845
RG 7845
Fenebrutinib HCl
Fenebrutinib (GDC-0853) HCl | [Molecular Formula]
C37H45ClN8O4 | [MOL File]
2128304-54-9.mol | [Molecular Weight]
701.27 |
| Hazard Information | Back Directory | [Description]
Fenebrutinib, also known as GDC-0853, is orally available inhibitor of Bruton's tyrosine kinase (BTK) with potential antineoplastic activity. Upon administration, GDC-0853 inhibits the activity of BTK and prevents the activation of the B-cell antigen receptor (BCR) signaling pathway. This prevents both B-cell activation and BTK-mediated activation of downstream survival pathways, which leads to the inhibition of the growth of malignant B-cells that overexpress BTK. BTK, a member of the Src-related BTK/Tec family of cytoplasmic tyrosine kinases, is overexpressed in B-cell malignancies; it plays an important role in B-lymphocyte development, activation, signaling, proliferation and survival. |
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| Company Name: |
InvivoChem
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| Tel: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
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