| Identification | Back Directory | [Name]
5,8,11,14-Tetraoxa-2-azaheptadecanedioic acid, 1,17-bis(1,1-dimethylethyl) ester | [CAS]
2138484-13-4 | [Synonyms]
Boc-NH-PEG4-C2-Boc
5,8,11,14-Tetraoxa-2-azaheptadecanedioic acid, 1,17-bis(1,1-dimethylethyl) ester | [Molecular Formula]
C20H39NO8 | [MOL File]
2138484-13-4.mol | [Molecular Weight]
421.53 |
| Chemical Properties | Back Directory | [Boiling point ]
497.2±40.0 °C(Predicted) | [density ]
1.053±0.06 g/cm3(Predicted) | [form ]
Liquid | [pka]
12.23±0.46(Predicted) | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Biological Activity]
Boc-NH-PEG4-C2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. | [References]
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
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