| Identification | Back Directory | [Name]
KEA1-97 | [CAS]
2138882-71-8 | [Synonyms]
KEA1-97
KEA1-97 >=98% (HPLC)
1,3,5-Triazin-2-amine, 4,6-dichloro-N-(4'-fluoro[1,1'-biphenyl]-4-yl)- | [Molecular Formula]
C15H9Cl2FN4 | [MDL Number]
MFCD31697744 | [MOL File]
2138882-71-8.mol | [Molecular Weight]
335.16 |
| Chemical Properties | Back Directory | [Boiling point ]
530.3±52.0 °C(Predicted) | [density ]
1.466±0.06 g/cm3(Predicted) | [storage temp. ]
4°C, protect from light | [solubility ]
DMSO : 100 mg/mL (298.36 mM; Need ultrasonic) | [form ]
Solid | [pka]
0.57±0.10(Predicted) | [color ]
White to light yellow |
| Hazard Information | Back Directory | [Description]
KEA1-97 is a Thioredoxin-Caspase 3 interaction disruptor. It was found to target lysine 72 of thioredoxin, inhibiting its interactions with caspase 3 and inducing apoptosis without affecting other thioredoxin activity. KEA1-97 induced apoptosis in breast cancer cells and treatment of immune-deficient SCID mice at 5 mg/kg ip impaired breast tumor xenograft growth. | [storage]
4°C, protect from light |
|
| Company Name: |
DC Chemicals
|
| Tel: |
021-58447131 13564518121 |
| Website: |
https://www.chemicalbook.com/ShowSupplierProductsList927327/0.htm |
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
InvivoChem
|
| Tel: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
|