| Identification | Back Directory | [Name]
HEPARIN, SODIUM, LOW MOLECULAR WEIGHT | [CAS]
21416-88-6 | [Synonyms]
Brn 3981691
meso-2,3-Bis(3,5-dioxopiperazin-1-yl)butane
meso-2,3-Bis(3,5-dioxopiperazine-1-yl)butane
ICRF-193 apoptosis inducer, arabinosidase substrate
2,6-Piperazinedione, 4,4'-(1,2-dimethylethylene)di-, meso-
2,6-Piperazinedione, 4,4'-(1,2-dimethyl-1,2-ethanediyl)bis-, rel-
2,6-Piperazinedione, 4,4'-(1,2-dimethyl-1,2-ethanediyl)bis-, (R*,S*)-
2,6-Piperazinedione, 4,4'-[(1R,2S)-1,2-dimethyl-1,2-ethanediyl]bis-, rel- | [Molecular Formula]
C12H18N4O4 | [MDL Number]
MFCD01702964 | [MOL File]
21416-88-6.mol | [Molecular Weight]
282.3 |
| Hazard Information | Back Directory | [Uses]
ICRF-193 has been used as a topoisomerase II (TOP2) inhibitor to treat mouse oocytes to investigate the role of TOP2 in meiosis. | [Definition]
ChEBI: ICRF-193 is an N-alkylpiperazine that is butane which is substituted by a 3,5-dioxopiperazin-1-yl group at positions 2 and 3. The meso isomer. It has a role as an EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor, an apoptosis inducer and an antineoplastic agent. | [General Description]
ICRF-193 is a bisdiopiperazine derivative. It inhibits topoisomerase II by forming a non-cleavable?complex. | [Biochem/physiol Actions]
ICRF-193 induces a G2 checkpoint that is associated with an ATR-dependent inhibition of polo-like kinase 1 (plk1) activity and a decrease in cyclin B1 phosphorylation. Induces apoptosis in several cell lines including K562 and Molt-4 cells., ICRF-193 is a topoisomerase II inhibitor, more potent against topoisomerase II-β than topoisomerase II-α, and may in addition cause DNA strand breaks. |
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