| Identification | Back Directory | [Name]
Pregn-7-ene-3,21-diol, 20-methyl-, 3-acetate 21-formate, (3β,5α,20S)- | [CAS]
2143952-36-5 | [Synonyms]
Pregn-7-ene-3,21-diol, 20-methyl-, 3-acetate 21-formate, (3β,5α,20S)- | [Molecular Formula]
C25H38O4 | [MOL File]
2143952-36-5.mol | [Molecular Weight]
402.58 |
| Chemical Properties | Back Directory | [Boiling point ]
482.0±45.0 °C(Predicted) | [density ]
1.09±0.1 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
Chloroform: 10 mg/ml | [form ]
A solid | [color ]
White to off-white |
| Hazard Information | Back Directory | [Biological Activity]
SH-42 is an inhibitor of ?24-dehydrocholesterol reductase (DHCR24; IC50 = 4.2 nM).1 It increases serum levels of desmosterol , the immediate precursor of cholesterol in the Bloch pathway, in mice when administered at a dose of 0.5 mg/animal per day. SH-42 increases levels of arachidonic acid and its metabolite prostaglandin E2 , as well as docosahexaenoic acid and its metabolites 19,20-EpDPA and 19,20-DiHDPA, in the peritoneal lavage fluid in a mouse model of peritonitis induced by zymosan A .2 | [storage]
-20°C | [References]
1.Müller, C., Hemmers, S., Bartl, N., et al.New chemotype of selective and potent inhibitors of human delta 24-dehydrocholesterol reductaseEur. J. Med. Chem.140305-320(2017)
2.K?rner, A., Zhou, E., Müller, C., et al.Inhibition of δ24-dehydrocholesterol reductase activates pro-resolving lipid mediator biosynthesis and inflammation resolutionProc. Natl. Acad. Sci. USA116(41)20623-20634(2019)
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