| Identification | Back Directory | [Name]
AMT HYDROCHLORIDE | [CAS]
21463-31-0 | [Synonyms]
AMT HCL
AMT HYDROCHLORIDE
2-AMINO-5,6-DIHYDRO-6-METHYL-4H-1,3-THIAZINE HCL
5,6-DIHYDRO-6-METHYL-4H-1,3-THIAZIN-2-AMINE, HYDROCHLORIDE
2-AMINO-5,6-DIHYDRO-6-METHYL-4H-1,3-THIAZINE HYDROCHLORIDE | [Molecular Formula]
C5H11ClN2S | [MDL Number]
MFCD00792731 | [MOL File]
21463-31-0.mol | [Molecular Weight]
166.67 |
| Chemical Properties | Back Directory | [Appearance]
white to off-white powder | [Melting point ]
146-150°C | [storage temp. ]
0-6°C | [solubility ]
DMF: >8 mg/ml; DMSO: >16 mg/ml; Ethanol: >25 mg/ml; Water: >25 mg/ml | [form ]
A crystalline solid | [Water Solubility ]
Soluble to 10 mM in water |
| Hazard Information | Back Directory | [Chemical Properties]
white to off-white powder | [Biological Activity]
Potent, selective and reversible inhibitor of iNOS (IC 50 = 3.6 nM; approximately 30 and 40 times selective over nNOS and eNOS respectively). | [Description]
AMT is a potent, relatively selective inhibitor of iNOS with a Ki of 4.2 nM in mouse macrophages. It inhibits other isoforms of NOS, but at higher concentrations; the IC50 values for rat nNOS and bovine eNOS are 34 and 150 nM, respectively. | [Uses]
AMT Hydrochloride is a potent and selective inhibitors of inducible nitric oxide synthase, which may lead to therapeutic applications in the treatment of inflammatory and autoimmune diseases. | [storage]
Store at -20°C |
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