| Identification | Back Directory | [Name]
4-[[(2,3-Dihydro-1,1,3,3-tetramethyl-2-oxo-1H-inden-5-yl)carbonyl]amino]-benzoic acid | [CAS]
215307-86-1 | [Synonyms]
Benzoic acid, 4-[[(2,3-dihydro-1,1,3,3-tetramethyl-2-oxo-1H-inden-5-yl)carbonyl]amino]- | [Molecular Formula]
C21H21NO4 | [MDL Number]
MFCD18384955 | [MOL File]
215307-86-1.mol | [Molecular Weight]
351.4 |
| Hazard Information | Back Directory | [Uses]
BMS 753 is as been reported to be a RARα-selective agonist. Used to develop a series of small molecule inhibitors which affect specific microscopic steps of Aβ42 aggregation in Alzheimer’s disease. This would aspire to reduce the attrition problem in drug discovery. | [Biological Activity]
BMS 753 is a subtype-selective retinoic acid receptor alpha (RARα) agonist with a Ki value of 2 nM for RARα. | [in vitro]
BMS 753 results in low levels of RARβ transcripts in WT cells, RARγ -/- , but not activates in RARa -/- cells.
| [target]
| [storage]
Store at RT |
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BOC Sciences
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https://www.bocsci.com |
| Company Name: |
Energy Chemical
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021-58432009 400-005-6266 |
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http://www.energy-chemical.com |
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