| Identification | Back Directory | [Name]
1-Benzyl 4-(tert-butyl) (S)-2-(cyanomethyl)piperazine-1,4-dicarboxylate | [CAS]
2158302-00-0 | [Synonyms]
2-Cyanomethyl-piperazine-1,4-dicarboxylic acid 1-benzyl ester 4-tert-butyl ester
1,4-Piperazinedicarboxylic acid, 2-(cyanomethyl)-, 4-(1,1-dimethylethyl) 1-(phenylmethyl) ester, (2S)- | [Molecular Formula]
C19H25N3O4 | [MOL File]
2158302-00-0.mol | [Molecular Weight]
359.42 |
| Hazard Information | Back Directory | [Chemical Properties]
White solid | [Synthesis]
Dissolve (S)-3-(cyanomethyl)piperazine-1-carboxylic acid tert-butyl ester (2.25g, 10mmol) in 15mL dichloromethane, add N,N-diisopropylethylamine at room temperature (3.87g, 30mmol) was cooled to 0°C, benzyl chloroformate was added dropwise, and reacted at low temperature for 2h. Add 25 mL of water to the reaction solution, extract the aqueous phase with dichloromethane (30 mL×3), combine the organic phases, wash the organic phase with water (20 mL×2), dry with anhydrous sodium sulfate, concentrate, and separate and purify the crude product by silica gel column chromatography (Ethyl acetate/petroleum ether (v/v)=1:20-1:5) to obtain 1-Benzyl 4-(tert-butyl) (S)-2-(cyanomethyl)piperazine-1,4-dicarboxylate (3.1 g, yield: 86%).
 |
|
|