| Identification | Back Directory | [Name]
etomidoline | [CAS]
21590-92-1 | [Synonyms]
K 2680
Nonspa
Smedolin
Amidoline
etomidoline
Phthalimidine, 2-ethyl-3-(β-piperidino-p-phenetidino)- (8CI)
2-Ethyl-2,3-dihydro-3-[4-(2-piperidinoethoxy)anilino]-1H-isoindol-1-one
2-Ethyl-2,3-dihydro-3-[[4-[2-(1-piperidinyl)ethoxy]phenyl]amino]-1H-isoindol-1-one
1H-Isoindol-1-one, 2-ethyl-2,3-dihydro-3-[[4-[2-(1-piperidinyl)ethoxy]phenyl]amino]- | [EINECS(EC#)]
244-463-9 | [Molecular Formula]
C23H29N3O2 | [MDL Number]
MFCD00867691 | [MOL File]
21590-92-1.mol | [Molecular Weight]
379.5 |
| Chemical Properties | Back Directory | [Melting point ]
106-107° | [Boiling point ]
507.34°C (rough estimate) | [density ]
1.1315 (rough estimate) | [refractive index ]
1.6500 (estimate) | [pka]
8.75±0.10(Predicted) |
| Hazard Information | Back Directory | [Originator]
Smedolin,Yamanouchi,Japan,1976 | [Definition]
ChEBI: Etomidoline is an organic molecular entity. | [Manufacturing Process]
31.3 g of 1-oxo-3-(aminophenyl-p-ethoxypiperidino)-isoindoline (0.0892 mol)
are dissolved in 500 ml of anhydrous N,N-dimethylformamide. To this solution
5.75 g of NaH (0.105 mol) and 7.24 ml of CH2CH2I (0.0945 mol) are added
and the resulted mixture is heated at 70°C for 1 hour, and then poured into
an excess of water. 1-oxo-2-ethyl-3-(aminophenyl-p-ethoxypiperidino)-
isoindoline (MP 106°C to 107°C) is obtained by crystallization with ligroin.
1-oxo-2-ethyl-3-(iminophenyl-p-ethoxypiperidino)-isoindoline (MP 103°C to
104°C) is obtained as a byproduct with the above compound. This latter
compound was reduced to produce 1-oxo-2-ethyl-3-(aminophenyl-p-ethoxypiperidino)-isoindoline. | [Therapeutic Function]
Muscle relaxant |
|
|