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ChemicalBook--->CAS DataBase List--->2170136-65-7

2170136-65-7

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2170136-65-7 Structure

2170136-65-7 Structure
IdentificationBack Directory
[Name]

GSK-3484862
[CAS]

2170136-65-7
[Synonyms]

GSK-3484862
[Molecular Formula]

C19H19N5OS
[MDL Number]

MFCD32708516
[MOL File]

2170136-65-7.mol
[Molecular Weight]

365.45
Chemical PropertiesBack Directory
[Boiling point ]

620.5±55.0 °C(Predicted)
[density ]

1.30±0.1 g/cm3(Predicted)
[solubility ]

DMSO:20.83(Max Conc. mg/mL);57.0(Max Conc. mM)
[form ]

Solid
[pka]

14.62±0.50(Predicted)
[color ]

Light yellow to yellow
Hazard InformationBack Directory
[Description]

GSK-3484862 is a non-covalent inhibitor for Dnmt1. GSK-3484862 induces DNA hypomethylation to against cancer.
[in vitro]

In total, methylation mapping supports the conclusion that GSK-3484862 treatment produces a drop in DNA methylation consistent with selective and near complete inhibition of DNMT1._x000D_ _x000D_ Reference: Epigenetics Chromatin. 2021 Dec 15;14(1):56. https://pubmed.ncbi.nlm.nih.gov/34906184/
[target]

GSK-3484862 is a non-covalent inhibitor for DNA methyltransferase (Dnmt1). GSK-3484862 induces DNA hypomethylation to against cancer.
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