2173201-65-3

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2173201-65-3 Structure

Chemical Properties	Back Directory
[density ] 1.461±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
[pka] 11.46±0.70(predicted)

Hazard Information	Back Directory
[Uses] PAR4 antagonist 1 (Compound 48) is a protease activated receptor 4 (PAR4) antagonist with an IC50 of 1.8 nM. PAR4 antagonist 1 has an IC50 of 2 nM against γ-thrombin-activated PAR4 in platelet-rich plasma (PRP). PAR4 antagonist 1 can be used in antithrombotic research[1].
[IC 50] PAR4: 1.8 nM (IC₅₀)
[References] [1] Zhang X, et al. Discovery of Potent and Selective Quinoxaline-Based Protease-Activated Receptor 4 (PAR4) Antagonists for the Prevention of Arterial Thrombosis. J Med Chem. 2024 Feb 22. DOI:10.1021/acs.jmedchem.3c01986

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