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2180914-37-6

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2180914-37-6 Structure

2180914-37-6 Structure
IdentificationBack Directory
[Name]

VU6005806
[CAS]

2180914-37-6
[Synonyms]

VU6005806
AZN-00016130
VU6005806,VU-6005806
[Molecular Formula]

C17H16F3N7O2S
[MDL Number]

MFCD32067965
[MOL File]

2180914-37-6.mol
[Molecular Weight]

439.41
Chemical PropertiesBack Directory
[storage temp. ]

Store at -20°C
[solubility ]

Soluble in DMSO
Hazard InformationBack Directory
[Description]

VU6005806 (AZN-00016130) is a potent muscarnic acethylcholine receptor subtype 4 (M4) positive allosteric modulator (PAM), with EC50s of 94 nM, 28 nM, 87 nM and 68 nM for human, rat, dog and cyno M4, respectively. Used in the research of neuropsychiatric disorders[1]. IC50: 94 nM (Human M4), 28 nM (Rat M4), 87 nM (Dog M4), 68 nM (Cyno M4)[1]

[References]

[1]. Engers DW, et al. VU6005806/AZN-00016130, an advanced M4 positive allosteric modulator (PAM) profiled as a potential preclinical development candidate. Bioorg Med Chem Lett. 2019 Jul 15;29(14):1714-1718.
2180914-37-6 suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000 , +1-00000000000
Website: https://www.targetmol.com/
Company Name: Fan De(Beijing) Biotechnology Co., Ltd.  
Tel: 15911056312
Website: www.bio-fount.com
Company Name: TargetMol Chemicals Inc.  
Tel: 4008200310
Website: https://www.targetmol.cn/
Company Name: Suzhou Zhixin Biotechnology Co., Ltd.  
Tel: 0512-65118909 15162312715
Website: www.szzxbio.com/
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