| Chemical Properties | Back Directory | [Boiling point ]
854.4±65.0 °C(Predicted) | [density ]
1.170±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF:1.0(Max Conc. mg/mL);1.46(Max Conc. mM)
DMSO:0.25(Max Conc. mg/mL);0.37(Max Conc. mM) | [form ]
A crystalline solid | [pka]
15.76±0.46(Predicted) | [color ]
white to beige |
| Hazard Information | Back Directory | [Description]
LH1306 is an inhibitor of the interaction between programmed cell death 1 (PD-1) and its ligand PD-L1. It increases the activation of Jurkat cells expressing PD-1 in co-culture with U2OS or CHO cells expressing PD-L1. | [in vitro]
C2-symmetric inhibitors 2a (LH1306) and 2b (LH1307) exhibited IC50 values of 25 and 3.0 nM, respectively, in the HTRF assay. In one cell-based coculture PD-1 signaling assay, 2a and 2b were 8.2- and 2.8-fold more potent in inhibiting PD-1 signaling than 1a and 1b, respectively._x000D_
_x000D_
Reference: J Med Chem. 2019 Aug 8;62(15):7250-7263. https://pubmed.ncbi.nlm.nih.gov/31298541/ | [target]
LH1306 is a novel potent inhibitor of the programmed cell death-1/programmed death-ligand 1 (PD-1/PD-L1) protein-protein interaction. | [storage]
Store at -20°C |
|
|