| Identification | Back Directory | [Name]
2-hydroxy-3-(phosphonooxy)propyl palmitate | [CAS]
22002-85-3 | [Synonyms]
Einecs 244-707-4
1-Palmitoyl lysophosphatidic acid
2-hydroxy-3-(phosphonooxy)propyl palmitate
1-Palmitoyl Lysophosphatidic Acid Exclusive
Palmitic acid 2-hydroxy-3-(phosphonooxy)propyl ester
2-hydroxy-3-(phosphonooxy)propyl ester Hexadecanoic acid
Hexadecanoic acid, 2-hydroxy-3-(phosphonooxy)propyl ester
1-Palmitoyl Lysophosphatidic Acid (1-Palmitoyl LPA free acid) | [EINECS(EC#)]
244-707-4 | [Molecular Formula]
C19H39O7P | [MDL Number]
MFCD18427958 | [MOL File]
22002-85-3.mol | [Molecular Weight]
410.48 |
| Chemical Properties | Back Directory | [Boiling point ]
560.6±60.0 °C(Predicted) | [density ]
1.112±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 2 mg/ml; DMSO: 2.5 mg/ml; Ethanol: 25 mg/ml; PBS (pH 7.2): 3 mg/ml | [form ]
A crystalline solid | [pka]
1.82±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
1-Palmitoyl lysophosphatidic acid (1-Palmitoyl LPA) is a LPA analog containing palmitic acid at the sn-1 position. LPA binds to one of at least five different G protein-coupled receptors to mediate a variety of biological responses including cell proliferation, smooth muscle contraction, platelet aggregation, neurite retraction, and cell motility.1,2 Additionally, 1-palmitoyl LPA enhances the action of β-lactam antibiotics (ampicillin, piperacillin, and ceftazidime) on various strains of P. aeruginosa, a pathogen associated with pulmonary disease and pneumonia, via binding both Ca2+ and Mg2+.3 | [Definition]
ChEBI: 1-palmitoylglycerol 3-phosphate is a monoacylglycerol phosphate having palmitoyl as the acyl group on O-1 and with the phosphate group on O-3. It is a conjugate acid of a 1-palmitoylglycerol 3-phosphate(2-). | [storage]
Store at -20°C | [References]
1. Noguchi, K., Ishii, S., and Shimizu, T. Identification of p2y9/GPR23 as a novel G protein-coupled receptor for lysophosphatidic acid, structurally distant from the Edg family J. Biol. Chem. 278(28),25600-25606(2003).
2. Moolenaar, W.H. LPA: A novel lipid mediator with diverse biological actions Trends Cell Biol. 4(6),213-219(1994).
3. Krogfelt, K.A., Utley, M., Krivan, H.C., et al. Specific phospholipids enhance the activity of β-lactam antibiotics against Pseudomonas aeruginosa J. Antimicrob. Chemother. 46(3),377-384(2000). |
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