| Identification | Back Directory | [Name]
17-TRIFLUOROMETHYLPHENYL TRINOR PROSTAGLANDIN F2ALPHA | [CAS]
221246-34-0 | [Synonyms]
CMLNDCUXASGBMQ-NQUQXYBYSA-N
17-trifluoromethylphenyl trinor Prostaglandin F2α
17-TRIFLUOROMETHYLPHENYL TRINOR PROSTAGLANDIN F2ALPHA
9ALPHA,11ALPHA,15S-TRIHYDROXY-17-TRIFLUOROMETHYLPHENYL-18,19,20-TRINOR-PROSTA-5Z,13E-DIEN-1-OIC ACID
5-Heptenoic acid, 7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3S)-3-hydroxy-5-[3-(trifluoromethyl)phenyl]-1-penten-1-yl]cyclopentyl]-, (5Z)- | [Molecular Formula]
C24H31F3O5 | [MDL Number]
MFCD05863954 | [MOL File]
221246-34-0.mol | [Molecular Weight]
456.5 |
| Chemical Properties | Back Directory | [Boiling point ]
593.0±50.0 °C(Predicted) | [density ]
1.296±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 30 mg/ml; DMSO: 25 mg/ml; Ethanol: 50 mg/ml; PBS (pH 7.2): 1 mg/ml | [pka]
4.76±0.10(Predicted) |
| Hazard Information | Back Directory | [Description]
A number of 17-phenyl trinor prostaglandin F2α (17-phenyl trinor PGF2α) derivatives have been approved for the treatment of glaucoma. Of these, the unsubstituted or meta-substituted aromatic derivatives are the most potent FP receptor agonists. 17-trifluoromethylphenyl trinor PGF2α bears an aromatic ring which is reminiscent of the trifluoromethyl-phenoxy ring of travoprost ((+)-fluprostenol isopropyl ester). As an ocular hypotensive agent, it would be expected that 17-trifluoromethylphenyl trinor PGF2α would act very much like the free acid of travoprost. 17-phenyl trinor PGF2α is a potent luteolytic and abortifacient, with a potency equal to or greater than fluprostenol and cloprostenol. | [storage]
Store at -20°C |
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