| Identification | Back Directory | [Name]
ALCLOFENAC | [CAS]
22131-79-9 | [Synonyms]
Argun
w7320
W 7320
MY 101
Epinal
Mervan
Neosten
Neoston
Zumaril
Reufenac
Medifenac
Aclofenac
Prinalgin
Alcorenac
Allopydin
ALCLOFENAC
BRN 2116510
Alclophenac
4-allyloxy-3-chlorophenyl-aceticaci
kyselina4-allyloxy-3-chlorfenyloctova
Kyselina 4-allyloxy-3-chlorfenyloctova
4-(Allyloxy)-3-chlorobenzeneacetic acid
(4-ALLYLOXY-3-CHLORO-PHENYL)-ACETIC ACID
[3-Chloro-4-(allyloxy)phenyl]acetic acid
2-(4-allyloxy-3-chloro-phenyl)acetic acid
3-chloro-4-(2-propenyloxy)-benzeneaceticaci
3-chloro-4-(2-propenyloxy)benzeneaceticacid
Acetic acid, [4-(allyloxy)-3-chlorophenyl]-
2-(3-chloro-4-prop-2-enoxyphenyl)acetic acid
3-Chloro-4-(2-propenyloxy)benzeneacetic acid
3-Chloro-4-(2-propen-1-yloxy)benzeneacetic Acid
2-(3-chloro-4-prop-2-enoxy-phenyl)ethanoic acid
Benzeneacetic acid, 3-chloro-4-(2-propenyloxy)-
Benzeneacetic acid, 3-chloro-4-(2-propen-1-yloxy)- | [EINECS(EC#)]
244-795-4 | [Molecular Formula]
C11H11ClO3 | [MDL Number]
MFCD00071612 | [MOL File]
22131-79-9.mol | [Molecular Weight]
226.66 |
| Chemical Properties | Back Directory | [Melting point ]
90-91°C | [Boiling point ]
324.6°C (rough estimate) | [density ]
1.2401 (rough estimate) | [refractive index ]
1.4530 (estimate) | [storage temp. ]
Refrigerator | [solubility ]
Chloroform (Slightly), Methanol (Slightly) | [form ]
Solid | [pka]
pKa 10.3 (Uncertain) | [color ]
Off-White to Pale Yellow | [Water Solubility ]
13.1mg/L(25 ºC) |
| Hazard Information | Back Directory | [Chemical Properties]
Off-White to Pale Yellow Solid | [Originator]
Allopydin ,Chugai ,Japan ,1976 | [Uses]
Analgesic; antipyretic; anti-inflammatory. | [Definition]
ChEBI: An aromatic ether in which the ether oxygen links an allyl group to the 4-position of (3-chlorophenyl)acetic acid.A non-steroidal anti-inflammatory drug, it was withdrawn from the UK market in 1979 due to concerns with its association with vasculitis and r
sh. | [Manufacturing Process]
103.7 grams of 3-chloro-4-allyloxyphenylacetonitrile in 500 cc of ethanol, 100
grams of potassium hydroxide and 100 cc of water are refluxed for 4 hours.
Maximum of alcohol is evaporated, the residue is diluted with water and ice,
and acidified with 20% HCl. The solid is filtered and washed with petroleum
ether. 91.5 grams of acid are obtained (Yield: 81%) which is recrystallized
from aqueous methanol; MP 92-93°C. | [Brand name]
Mervan (Continental
Pharma, Belgium);Allopydinac;Alopidin;Alopydin;Argan;Darkeyfenac;Desinflam;Medifenac;Mevan;Mirvan a;Prinalgin;Vanadian;W-7320;Zubirol. | [Therapeutic Function]
Antiinflammatory | [World Health Organization (WHO)]
Alclofenac, a phenylacetic acid derivative with analgesic,
antipyretic and antiinflammatory activity, was introduced in 1972 for the treatment
of rheumatic disorders. In the late 1970s its use was associated with a high
incidence of adverse effects, mainly skin rashes, and a urinary metabolite was reported to have mutagenic activity (positive Ames test). This resulted in the
withdrawal of the drug, in some cases voluntarily, from several countries. In others
registration has been refused. The reported mutagenic potential has been
questioned by some investigators and the drug remains on the market in at least
three countries with highly evolved regulatory authorities. |
|
| Company Name: |
Struchem Co., Ltd.
|
| Tel: |
0512-0512-63009836 15365350169 |
| Website: |
http://www.struchem.com |
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
InvivoChem
|
| Tel: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
|