| Identification | Back Directory | [Name]
Guanadrel HeMisulfate | [CAS]
22195-34-2 | [Synonyms]
Anarel
Hylorel
CL-1388R
U-28288D
Hyloride
CHEBI:5556
Guanadrel HeMisulfate
GUANADREL SULFATE (200 MG)
(1,4-Dioxaspiro[4.5]dec-2-ylMethyl)guanidine Sulfate
N-(1,4-Dioxaspiro[4.5]dec-2-ylMethyl)guanidine Sulfate
1-(1,4-Dioxaspiro[4.5]decan-2-ylmethyl)guanidine Sulfate | [Molecular Formula]
C10H19N3O2.H2O4S | [MDL Number]
MFCD08141811 | [MOL File]
22195-34-2.mol | [Molecular Weight]
311.357 |
| Hazard Information | Back Directory | [Uses]
Guanadrel is an orally active postganglionic sympathetic inhibitor. Guanadrel HeMisulfate is used as an antihypertensive.
| [Uses]
Guanadrel is an orally active postganglionic sympathetic inhibitor. Guanadrel is used as an antihypertensive. | [Definition]
ChEBI: A sulfate salt resulting from the reaction of 2 eq. guanadrel with 1 eq. sulfuric acid. A postganglionic adrenergic blocking agent formerly used for the management of hypertension, it has been largely superseded by other drugs less likely to cause orthosta
ic hypotension (dizzy spells on standing up or stretching). | [Brand name]
Hylorel (Pharmacia & Upjohn). | [General Description]
Guanadrel sulfate, (1,4-dioxaspiro[4.5]dec-2-ylmethyl)guanadine sulfate (Hylorel), issimilar to guanethidine monosulfate in the manner in whichit reduces elevated blood pressure. It acts as a postganglionicadrenergic blocking agent by displacing norepinephrinein adrenergic neuron storage granules, therebypreventing release of the endogenous neurotransmitter onnerve stimulation. Guanadrel sulfate has a much shorterhalf-life (10 hours) than guanethidine monosulfate, whose half-life is measured in days. In the stepped-care approachto hypertension, guanadrel sulfate is usually a step 2 agent. |
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| Company Name: |
Energy Chemical
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| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
Whyte Chemicals
|
| Tel: |
+44 (20) 8346-5946 |
| Website: |
www.whytechemicals.co.uk |
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