| Chemical Properties | Back Directory | [Boiling point ]
773.0±60.0 °C(Predicted) | [density ]
1.093±0.06 g/cm3(Predicted) | [form ]
Oil | [pka]
12.23±0.46(Predicted) | [color ]
Colorless to off-white |
| Hazard Information | Back Directory | [Biological Activity]
Boc-NH-PEG15-NH2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. | [References]
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
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