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2222755-14-6

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2222755-14-6 Structure

2222755-14-6 Structure
IdentificationBack Directory
[Name]

LOXO-292
[CAS]

2222755-14-6
[Synonyms]

LOX0292
RET-IN-1
Pyrazolo[1,5-a]pyridine-3-carbonitrile, 4-[5-[6-[(6-methoxy-3-pyridinyl)methyl]-3,6-diazabicyclo[3.1.1]hept-3-yl]-2-pyrazinyl]-6-[(2R)-2-morpholinylmethoxy]-
[Molecular Formula]

C29H31N9O3
[MDL Number]

MFCD32062760
[MOL File]

2222755-14-6.mol
[Molecular Weight]

553.61
Chemical PropertiesBack Directory
[density ]

1.49±0.1 g/cm3(Predicted)
[storage temp. ]

Dry, dark and at 0 - 4℃ for short term (days to weeks) or -20℃ for long term (months to years).
[solubility ]

Soluble in DMSO
[form ]

solid
[pka]

8.23±0.40(Predicted)
Hazard InformationBack Directory
[Description]

RET-IN-1 is an oral and selective investigational drug in clinical development for the treatment of patients with cancers that harbor abnormalities in the rearranged during transfection (RET) kinase.
[Mechanism of action]

Receptor tyrosine kinase RET (rearranged during transfection) inhibitor
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