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2225728-57-2

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2225728-57-2 Structure

2225728-57-2 Structure
IdentificationBack Directory
[Name]

FT-895)
[CAS]

2225728-57-2
[Synonyms]

FT-895)
FT895 (FT 895
1H-Isoindole-4-carboxamide, 2,3-dihydro-N-hydroxy-1,1-dimethyl-2-[5-(trifluoromethyl)-2-pyrazinyl]-
[Molecular Formula]

C16H15F3N4O2
[MDL Number]

MFCD31813663
[MOL File]

2225728-57-2.mol
[Molecular Weight]

352.31
Chemical PropertiesBack Directory
[storage temp. ]

Store at -20°C
[solubility ]

DMSO : 125 mg/mL (354.80 mM; Need ultrasonic)
[form ]

Solid
[color ]

White to light yellow
Hazard InformationBack Directory
[Biological Activity]

FT895 is a potent and selective HDAC11 inhibitor with an IC50 of 3 nM[1]. FT895 is a highly selective HDAC11 inhibitor showing greater than 1000-fold selectivity against the other 10 members of the HDAC family[1].
[References]

[1]. Martin MW, et al. Discovery of novel N-hydroxy-2-arylisoindoline-4-carboxamides as potent and selective inhibitors of HDAC11. Bioorg Med Chem Lett. 2018 Jul 1;28(12):2143-2147.
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