| Identification | Back Directory | [Name]
Photoswitchable PAD Inhibitor (technical grade) | [CAS]
2226393-62-8 | [Synonyms]
Photoswitchable PAD Inhibitor (technical grade) | [Molecular Formula]
C26H26ClN7O | [MOL File]
2226393-62-8.mol | [Molecular Weight]
487.98 |
| Hazard Information | Back Directory | [Description]
Photoswitchable PAD inhibitor is a photoactivated protein arginine deiminase (PAD) inhibitor and a derivative of BB-Cl-amidine that contains an azobenzene photoswitch allowing optical control of PAD activity. Without photoactivation, it is a weak inhibitor of PAD2 and is less potent than BB-Cl-amidine in inhibiting citrulline production in vitro. It does not inhibit histone H3 citrullination in HEK293T cells overexpressing PAD2. However, it can rapidly be photoactivated with UV-A radiation to the more active cis-isomer, which is an irreversible, competitive inhibitor of histone H3 citrullination. | [storage]
Store at -20°C |
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