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2227008-67-3

2227008-67-3 Structure

2227008-67-3 Structure
IdentificationBack Directory
[Name]

INDEX NAME NOT YET ASSIGNED
[CAS]

2227008-67-3
[Synonyms]

93 O17S,93-O-17S,93O17S
[Molecular Formula]

C44H83N3O4S2
[MOL File]

2227008-67-3.mol
[Molecular Weight]

782.29
Chemical PropertiesBack Directory
[Boiling point ]

812.2±65.0 °C(Predicted)
[density ]

1.01±0.1 g/cm3(Predicted)
[storage temp. ]

-20°C
[solubility ]

Chloroform: 100 mg/ml
[form ]

Oil
[pka]

7.10±0.50(Predicted)
[color ]

Light yellow to yellow
Safety DataBack Directory
[Symbol(GHS) ]


GHS02,GHS07
[Signal word ]

Danger
[Hazard statements ]

H225-H319
[Precautionary statements ]

P210-P233-P240-P241-P242-P243-P264-P280-P303+P361+P353-P305+P351+P338-P337+P313-P370+P378-P403+P235-P501
Hazard InformationBack Directory
[Biological Activity]

93-O17S is a chalcogen-containing cationic lipidoid.1 It has been used in the synthesis of lipid nanoparticles (LPNs) for the delivery of Cre recombinase and ribonucleoproteins for genome editing in mice. LPNs containing 93-O17S have been used for the intratumoral delivery of cGAMP to enhance cross-presentation of tumor antigens and stimulation of interferon genes (STING) activation in a B16/F10 murine melanoma model.2
[References]

1.Li, Y., Yang, T., Yu, Y., et al.Combinatorial library of chalcogen-containing lipidoids for intracellular delivery of genome-editing proteinsBiomaterials178652-662(2018) 2.Chen, J., Qiu, M., Ye, Z., et al.In situ cancer vaccination using lipidoid nanoparticlesSci. Adv.7(19)eabf1244(2021)
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