ChemicalBook--->CAS DataBase List--->2229042-77-5

2229042-77-5

2229042-77-5 Structure

2229042-77-5 Structure
IdentificationBack Directory
[Name]

ZL0454
[CAS]

2229042-77-5
[Synonyms]

ZL0454
[Molecular Formula]

C18H22N4O3S
[MDL Number]

MFCD31813659
[MOL File]

2229042-77-5.mol
[Molecular Weight]

374.46
Chemical PropertiesBack Directory
[Boiling point ]

630.6±65.0 °C(Predicted)
[density ]

1.41±0.1 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

DMSO : 50 mg/mL (133.53 mM; Need ultrasonic)
[form ]

Solid
[pka]

9.30±0.36(Predicted)
[color ]

Brown to reddish brown
Hazard InformationBack Directory
[Biological Activity]

ZL0454 is a potent and selective Bromodomain-containing protein 4 (BRD4) inhibitor with an IC50 of 49 and 32 nM for BD1 and BD2.
[References]

[1]. Liu Z, et al. Discovery of potent and selective BRD4 inhibitors capable of blocking TLR3-induced acute airway inflammation. Eur J Med Chem. 2018 May 10;151:450-461.
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Tags:2229042-77-5 Related Product Information
49671-76-3 1181226-02-7 2229039-45-4

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