| Hazard Information | Back Directory | [Biological Activity]
PKI-166 hydrochloride is a potent, selective, and orally bioactive EGFR tyrosine kinase inhibitor with IC50 of 0.7 nM. | [in vivo]
PKI-166 hydrochloride (100 mg/kg; po; daily; for 29 days) inhibits of pancreatic cancer growth.
| Animal Model: < /td> | Male athymic nude mice with L3.6pl cells xenograft (8-12 weeks) | | Dosage: < /td> | 100 mg/kg | | Administration: | Oral administration; daily; for 29 days | | Result: | Significantly decreased median tumor volume. | | [target]
IC50: 0.7 nM (EGFR tyrosine kinase) | [storage]
Store at -20°C |
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