| Identification | Back Directory | [Name]
Urea, N-[4-[[(2S)-2-(4-morpholinylmethyl)-1-pyrrolidinyl]sulfonyl]phenyl]-N'-[4-(trifluoromethyl)phenyl]- | [CAS]
2230496-99-6 | [Synonyms]
ZL0590
Urea, N-[4-[[(2S)-2-(4-morpholinylmethyl)-1-pyrrolidinyl]sulfonyl]phenyl]-N'-[4-(trifluoromethyl)phenyl]- | [Molecular Formula]
C23H27F3N4O4S | [MOL File]
2230496-99-6.mol | [Molecular Weight]
512.55 |
| Hazard Information | Back Directory | [Biological Activity]
ZL0590 is a potent, orally active BRD4 BD1-selective inhibitor with an IC50 of 90 nM for human BRD4 BD1. ZL0590 exhibits significant anti-inflammatory activities[1]. | [References]
[1]. Liu Z, et al. Discovery, X-ray Crystallography, and Anti-inflammatory Activity of Bromodomain-containing Protein 4 (BRD4) BD1 Inhibitors Targeting a Distinct New Binding Site. J Med Chem. 2022;65(3):2388-2408. |
|
|