| Identification | Back Directory | [Name]
Foretinib-Based PROTAC 7 | [CAS]
2230821-68-6 | [Synonyms]
Foretinib-Based PROTAC 7
1-N'-[3-fluoro-4-[7-[3-[3-[3-[[(2R)-1-[(2R,4S)-4-hydroxy-2-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methylcarbamoyl]pyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]amino]-3-oxopropoxy]propoxy]propoxy]-6-methoxyquinolin-4-yl]oxyphenyl]-1-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide | [Molecular Formula]
C58H65F2N7O11S | [MOL File]
2230821-68-6.mol | [Molecular Weight]
1106.25 |
| Hazard Information | Back Directory | [Description]
SJF-8240 is a c-MET degrader. It comprises MET inhibitor foretinib joined by a linker to a von Hippel-Lindau (VHL) recruiting ligand. SJF-8240 degrades c-MET within 6 hours in vitro and inhibits agonist-driven AKT phosphorylation and GTL16 cell proliferation. It also degrades exon-14-deleted c-MET in Hs746T cells. | [storage]
Store at -20°C |
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