| Identification | Back Directory | [Name]
Amino-PEG5-t-butyl acetate | [CAS]
2231845-67-1 | [Synonyms]
NH2-PEG5-C1-Boc
NH2-PEG5-CH2COOtBu
H2N-PEG5-CH2COOtBu
Amino-PEG5-t-butyl acetate
tert-butyl 17-amino-3,6,9,12,15-pentaoxaheptadecanoate
3,6,9,12,15-Pentaoxaheptadecanoic acid,17-amino-, 1,1-dimethylethyl ester | [Molecular Formula]
C16H33NO7 | [MDL Number]
MFCD31747106 | [MOL File]
2231845-67-1.mol | [Molecular Weight]
351.44 |
| Hazard Information | Back Directory | [Biological Activity]
NH2-PEG5-C1-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. | [References]
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
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