Chemical Properties | Back Directory | [storage temp. ]
Sealed in dry,2-8°C | [solubility ]
DMSO:42.25(Max Conc. mg/mL);100.0(Max Conc. mM) Ethanol:42.25(Max Conc. mg/mL);100.0(Max Conc. mM) | [form ]
powder | [color ]
white to beige |
Hazard Information | Back Directory | [Biological Activity]
TH-257 is a potenttype III allosteric LIM-kinase (LIMK1 & LIMK2) inhibitor (LIMK1/2 IC50 in nM = 48/29 by cell-free kinase assay and 250/150 by live cell NanoBRET assay using respective transfectants) th at targets LIMK1/2 DFG-out conformation in a non-ATP-competitive manner and exhibits no significant off-target activity by KINOMEscan assay at 1 μM. TH-263 is a structure analog and the recommended negative control for TH-257. For characterization details of TH-257please visit the TH-257 probe summary on the Structural Genomics Consortium (SGC) website.
TH-263 is the negative control for the active probeTH-257. TH-263 is available from Sigma. To learn more about and purchase TH-263click here.
To learn about other SGC chemical probesvisit sigma.com/sgc | [storage]
Store at +4°C |
|
|