| Identification | Back Directory | [Name]
2-Benzothiazolepropanamide, N-[(1S)-1-cyclohexyl-2-[[2-[(dimethylamino)methyl]-1-oxo-2-propen-1-yl]amino]ethyl]-6-(1-methylethyl)-α-[(1-oxopropyl)amino]-, (αS)- | [CAS]
2247061-09-0 | [Synonyms]
2-Benzothiazolepropanamide, N-[(1S)-1-cyclohexyl-2-[[2-[(dimethylamino)methyl]-1-oxo-2-propen-1-yl]amino]ethyl]-6-(1-methylethyl)-α-[(1-oxopropyl)amino]-, (αS)- | [Molecular Formula]
C30H45N5O3S | [MOL File]
2247061-09-0.mol | [Molecular Weight]
555.78 |
| Chemical Properties | Back Directory | [Boiling point ]
806.1±65.0 °C(Predicted) | [density ]
1.138±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [form ]
Solid | [pka]
13.79±0.46(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Biological Activity]
DI-1859 is a potent, selective and covalent inhibitor of DCN1. DI-1859 inhibits neddylation of cullin 3 in cells at low nanomolar concentrations. DI-1859 induces a robust increase of NRF2 protein, a CRL3 substrate, in mouse liver and effectively protects mice from acetaminophen-induced liver damage[1]. | [References]
[1]. Zhou H, et al. Selective inhibition of cullin 3 neddylation through covalent targeting DCN1 protects mice from acetaminophen-induced liver toxicity. Nat Commun. 2021;12(1):2621. |
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