| Identification | Back Directory | [Name]
[3,3'-Bipyridine]-5-methanol, 2',4,6-trimethoxy-α-2-naphthalenyl- | [CAS]
2247911-68-6 | [Synonyms]
[3,3'-Bipyridine]-5-methanol, 2',4,6-trimethoxy-α-2-naphthalenyl- | [Molecular Formula]
C24H22N2O4 | [MOL File]
2247911-68-6.mol | [Molecular Weight]
402.45 |
| Hazard Information | Back Directory | [Biological Activity]
Lipoxygenin is an inhibitor of 5-lipoxygenase (5-LO) with an IC50 value of 5 μM for inhibition of 5-LO product synthesis in isolated human granulocytes stimulated with the cation ionophore A23187 .1 It inhibits hedgehog-dependent signaling in Shh-LIGHT2 cells and TGF-β-, activin A-, bone morphogenic protein (BMP)-, or Wnt-dependent signaling in HEK293T cells (IC50s = 9.3, 3.2, 8.2, 9.6, and 3.7 μM, respectively, in luciferase reporter assays). Lipoxygenin (5 and 10 μM) increases levels of troponin T (TnnT), a marker of cardiomyocyte differentiation, in human induced pluripotent stem cells (iPSCs) stimulated with BMP4 and the glycogen synthase kinase 3 (GSK3) inhibitor CHIR99021 . | [References]
1.Brand, S., Roy, S., Schr?der, P., et al.Combined proteomic and in silico target identification reveal a role for 5-lipoxygenase in developmental signaling pathwaysCell Chem. Biol.25(9)1095-1106(2018)
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